The Cranes will be hosting the Black Stars on November 15 in a must win game to enhance their chances of automatic qualification for next year’s finals.
Uganda managed to pick a point off Ghana in their first leg meeting in the opening Group E game in the qualifiers.
And Srejodevic is confident his side will rise up to the challenge once more and beat the star-studded Black Stars team just like the biblical David vrs Goliath story.
“The game against Ghana on November 15 is like a David and Goliath battle where my Uganda team will shock everybody after the game,” Sredojevic told Goal Ghana.
“We are fully aware of the threat Ghana come along with because there are a lot of individual qualities in their team and they are the only country to draw with world champions Germany at the 2014 Fifa World Cup, but we will not be pushovers.
“We have our nation to protect and make the people happy because this is a perfect opportunity to do so.”
Uganda are desperate for a win against Ghana to boost their chances of automatic qualification to the 2015 AFCON.
The Cranes are currently third in Group E with just four points with two games remaining.