Thousands of goods, including television sets and electronic appliances were destroyed in the early morning blaze.
Firefighters took several hours to bring it under control and Melcom officials say they are yet to ascertain the cost of damage.
Chief fire officer at the scene, Dr Albert Brown-Gaisie expressed concern about the increasing spate of incidents involving Melcom.
He insisted there is a need for officials of Melcom to fully cooperate with the fire service to conduct a proper safety assessment of their buildings.
Dr Gaisie called on the industries and institutions install better fire response mechanisms to minimize the extent of damage whenever there is a fire outbreak.
The installation of early warning systems for example, in his opinion, would provide early indications whenever there is a fire outbreak.
“When some of these industries have early warning systems, before these fires occur and get out of hand, there would have been some indication from an early warning system” he insisted.
However, he said, most industries are ignoring the safety measures with impunity.
He appealed to industries who do not have water on their premises to ensure that reservoirs be available on their premises, especially in light of the water situation.
Tragedy struck in 2012 when the Melcom Achimota branch building collapsed, killing 14 people and injuring over 78. A month later, fire gutted the Melcom Mall in Agona Swedru.
Police are still investigating a robbery at the Madina Melcom building, last December, in which a 53-year-old security man was murdered in cold blood.